Special Session
77 |
Theoretical, technical, and experimental challenges in closed-loop approaches in biology |
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Introduction:
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Characterization and control of nonlinear and non-stationary processes is an active topic in the general field of the applied theory of dynamical systems, and in the specific scope of complex biological systems. In this context classical control techniques cannot be applied straight away, and thus observation and actuation should be properly incorporated into a real-time feedback (or closed-loop) methodology. This being the case, modern activity-dependent stimulation protocols should be used to reveal dynamics (otherwise hidden under traditional stimulation techniques), achieve control of natural and pathological states, induce learning, bridge between disparate levels of analysis and for a further automation of experiments. Furthermore, closed-loop interaction calls for novel real time analysis, prediction and control tools and a new perspective for designing stimulus-response experiments, which can have a large impact in biological research.
In this special session the closed-loop methodology is discussed through recent contributions in both the theoretical and experimental study of biological systems. |
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