| Abstract: |
| We fit an ODE model of immune response by CD4$^+$ T cells to a time series of laboratory data from mice infected with lymphocytic choriomeningitis virus (LCMV). We considered two clonotypes of CD4$^+$ T cells, responding either to gp61 or NP309 LCMV epitopes. The model also includes the presence of regulatory CD4$^+$ T cells (Tregs) and interleukine-2 (IL-2) density. The non-linearity of this model allows the fit both to the immune activation phase triggered by the LCMV infection and to the subsequent relaxation phase, with a smooth transition from faster to slower death rates. |
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