| Abstract: |
| In this paper, we incorporate both virus-to-cell and cell-to-cell transmissions into an HIV-1 virus model with nonlinear general incidence rate, intracellular delay, and cytotoxic T lymphocyte (CTL) immune responses. By Lyapunov functionalsand LaSalle invariance principle, it is verified that global threshold dynamics of three equilibria, infection-free, CTL-inactivated and CTL-activated, can be explicitly described by the basic reproduction numbers. |
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