| Abstract: |
| We study the dynamical behaviors of coupled oscillators in different activity states with slow permittivity coupling in Epileptor model, including seizure like event (SLE), refractory status epilepticus (RSE), depolarization block (DB), and normal state. Our researches find that when one oscillator in normal states is coupled with any oscillator in SLE, RSE or DB states, both of these two oscillators can evolve into SLE states in the state of epileptiform synchronization or epileptiform anti-synchronization. Moreover, SLE can be suppressed while considering the fast electrical or chemical coupling. Additionally, a reduced model is also given to study the seizure dynamics with more coupling numbers. Those results can help to understand the dynamical mechanism of the formation, propagation and termination of seizures in focal epilepsy. |
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