| Abstract: |
| Radiotherapy is an effective tool in the treatment of cancerous tumors. There are a variety of dosing regimens that can be used, from a large single dose or a few large doses (hypofractionation) to many smaller doses (hyperfractionation). The effectiveness of each strategy depends on a number of factors, including the tumor volume and the surrounding organs at risk.
The most common tool for determining a time-dose relationship in radiotherapy is the Linear Quadratic (LQ) model. It has been shown that different mechanistic radiobiological models result in the LQ relationship for dose fractionation in some approximation.
In this study we determine the optimal radiation dosing strategy, using the full mechanistic models. We compare our results to those derived using the LQ formalism. |
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