| Abstract: |
| Networks of Rho-family GTPases regulate eukaryotic cell polarization and motility. In particular, the mutually inhibitory interactions between Rac and Rho are known to be critical in regulating a number of migratory processes. Here I discuss a simple model of these dynamics and show that this motif can account for diverse observations related to heterogeneity of cell shapes (contracted, spread, of polarized for example), motility type (amoeboid versus mesenchymal), as well as migratory persistence of cells. These results support the notion that Rac and Rho affect a multitude of migratory decisions and serve as a central regulatory hub interpreting an array of input signals. |
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