| Abstract: |
| Fucosyltransferase (FucT) is an enzyme that transfers fucose sugar to a sugar or protein, and Helicobacter plori in human causes both gastric and duodenal ulcers. Helicobacter plori \alpha-1,3 FucT is involved in the biosynthesis of the Lewis X trisaccharide of the lipopolysaccharide O-antigen. The function and structure of \alpha-1,3 FucT has been reported in these years, however the structure of \alpha-1,4 FucT has not.
The prior experiment shows that \alpha-1,4 FucT shares the function of \alpha-1,3 FucT, further the gene sequence of \alpha-1,4 FucT also indicates this enzyme might have two functions. Our goal is to predict the structures of \alpha-1,4 FucT, and compare these structures to other FucTs to verify the possibility of the dual functionalities of \alpha-1,4 FucT. |
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