| Abstract: |
| Antimicrobial de-escalation aims to minimize resistance to high-value broad-spectrum empiric antimicrobials by switching to alternative drugs when testing confirms susceptibility. Though widely practiced in ICUs, the effects of de-escalation are not well understood. We develop a high-dimensional ODE model to assess the effect of de-escalation on a broad range of outcomes, and clarify expectations. In this talk, I will present the medical background and conclusions of our first modelling results, and show how we numerically analyze the model output with a broad range of undetermined parameters and limited data. |
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