| Contents |
| The nuclear architecture plays an important role in organizing a function of nucleus that is composed of two chromatin domains called heterochromatin and euchromatin. Heterochromatin is more condensed chromatin in the lower level of transcript state and typically distributed at nuclear envelope and around the nucleoli. In contrast, euchromatin is less condensed in active transcriptional state and distributed in the nuclear interior between the perinuclear and heterochromatin domains.
The nuclear architecture described above is called Conventional Architecture and which is nearly universal in the vast majority of eukaryotic cells. On the other hand, there is very different nuclear architecture called Inverted Architecture, in which heterochromatin is gathered in the center of nuclear and euchromatin is enriched at nuclear envelope.
Interestingly, rod photoreceptor cell of mouse has inverted architecture induced by very dynamical remodeling of conventional architecture during terminal differentiation.
In this presentation, we regenerate the remodeling dynamics of chromatin architectures by novel approach of phase field method. We show how nuclear structures can change dynamically and create long-range spatial patterns without complex details of genetic information. |
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