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| The process of angiogenesis is regulated by the interactions between various cell types such as endothelial cells and macrophages, and by biochemical factors. In this talk, we present a hybrid mathematical model in which cells are treated as discrete units in a continuum field of a chemoattractant that evolves according to a system of reaction-diffusion equations, whereas the discrete cells serve as sources/sinks in this continuum field. It incorporates a realistic model for signal transduction and VEGF production and release, and gives insights into the aggregation patterns and the factors that influence stream formation. In particular, it serves as a tool for investigating tumor-vessel signaling and the role of mechano-chemical interactions of the cells with the substratum. |
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