Special Session 62: Mathematical models of cell migration, tumor growth and cancer dynamics
Contents
In this talk, we present a numerical simulation of glioma invasion using a two-dimensional hybrid method under physical constraints in the given microenvironment via the regulation of myosin II in response to chemoattractants. Gliomas are malignant tumors that are commonly observed in primary brain cancer. Experimentally it was known that glioma cells can use myosin II to migrate and invade surrounding brain tissue when injected into mouse brain. We investigated a mathematical model based on cell mechanics which predicts how glioma cells infiltrate the brain tissue under the complex biochemical and biomechanical signals. The model also predicts the myosin II plays an essential role in regulating the cell migration through fixed glial normal cells in the brain.