| Contents |
| We develop and optimize neuromodulation techniques for counteracting
of abnormal neuronal synchronization characteristic for several neurological
disorders like Parkinson's disease or tinnitus. An efficient stimulation
has to be of sufficient strength and duration, and too weak
stimulation may fail to desynchronize the stimulated neurons. For this
case we propose a novel stimulation approach which can sustainably shift
the neuronal population to a desynchronized regime by even weak stimulation,
where the conventional stimulation protocol does not work. We suggest
to stimulate the neuronal target population in an intermittent stop-and-go
manner, which explores multistable regimes induced in the neuronal network
by spike timing-dependent plasticity. The suggested approach is illustrated
on coordinated reset stimulation that has successfully been tested
in several experimental and clinical studies. Our findings can provide
an opportunity to reduce the stimulation intensity without affecting
the efficacy of the stimulation method, which may be of clinical relevance. |
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