We prove short-time well-posedness and existence of global weak solutions of the Beris--Edwards model for
nematic liquid crystals in the case of a domain with inhomogeneous Dirichlet boundary conditions. The system consists of the Navier-Stokes equations coupled with an evolution
equation for the Q-tensor. The solutions possess higher regularity in time of order one compared to the class of weak solutions with finite energy. This regularity is enough to obtain Lipschitz continuity of the non-linear terms in the corresponding function spaces. Therefore the well-posedness is shown with the aid of the contraction mapping principle using that the linearized system is an isomorphism between the associated function spaces.