| Abstract: |
| Parkinson`s disease (PD) is one of the most common neurodegenerative diseases. Clinical and experimental evidence suggests that, during the progression of PD, neurons within Cortex-basal ganglia-thalamus (CBGT) circuit exhibit the pathological phenomenon such as abnormal beta-band oscillation and excessive synchronization. To understand the influence of electromagnetic induction and the regulatory effect of electromagnetic stimulation in PD, we investigate physiological and pathological states within a CBGT network model. The results show that the magnetic induction plays a dual role: increasing the magnetic coefficient can not only lead physiological firing patterns to transition into pathological intense firing with enhanced beta band power, but also regulate pathological intense firing and transform it back into physiological firing with weak beta-band power. Moreover, external electromagnetic stimulation applied to the globus pallidus externa (GPe) and pyramidal neuron (PY) effectively suppresses intense firing patterns, beta-band power, and abnormal synchronization in STN, indicating a weakening of pathological oscillations. This work not only elucidates the dual regulatory mechanisms of electromagnetic induction on pathological oscillations in PD, but also provides theoretical foundations for developing noninvasive electromagnetic stimulation as a potential therapeutic strategy for PD. |
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