Special Session 87: Mathematical Insights into Phase-Field Models

A stochastic Allen-Cahn equation with jumps for radiotherapy damage
Luca Scarpa
Politecnico di Milano
Italy
Co-Author(s):    Andrea Di Primio, Marvin Fritz, Margherita Zanella
Abstract:
We present a stochastic Allen-Cahn equation for the dynamics of biomolecular damage and repair. The jump-type noise models the abrupt, localised damage induced by external radiotherapy shocks. We prove well-posedness of the model in a strong probabilistic sense and present some simulations to illustrate how it captures fundamental biological phenomena, such as damage clustering, stress-induced topology perturbations, and damage dynamics. The works presented in the talk are based on joint collaborations with Andrea Di Primio (Scuola Normale Superiore, Pisa, Italy), Marvin Fritz (University of Vienna, Austria), and Margherita Zanella (Politecnico di Milano, Italy).