Special Session 102: Mathematics of Cancer and Cardiovascular Dynamics: From High-Fidelity Simulation to Data-Driven Methods
Simple Mathematical Model of CAR-T Cells Therapy for Glioblastoma
Urszula Forys
University of Warsaw, Faculty of Mathematics, Informatics and Mechanics Poland
Co-Author(s): Juan Belmonte-Beitia, Marek Bodnar, Mariusz Bodzioch, Monika J. Piotrowska, Magdalena Szafra\`nska-\L{}\c{e}czycka
Abstract:
CAR-T (chimeric antigen receptor T) cell therapy is a novel immunotherapy that oncologists are trying to adapt to various types of cancer, including glioblastomas - brain tumors of glial origin. We consider a generalisation of the mathematical model proposed by Le\`{o}n-Triana et al. (2021) describing the competition of CAR-T and glioblastoma tumour cells. We focus on the mathematical properties of the proposed model, analyzing the stability of steady states, and then discuss two different types of treatments: constant and periodic, comparing their effectiveness.