| Abstract: |
| In this presentation, we investigate the role of time delay in regulating epithelial--mesenchymal transition within the model based on Celi\`{a}-Terrassa et al. (2018). From the perspective of cancer treatment, such temporal effects may influence the effectiveness of therapeutic strategies targeting TGF-$\beta$ pathways. Sensitivity analysis indicates that parameters associated with TGF-$\beta$ degradation and autocrine production play a key role in controlling E-cadherin levels and, consequently, cellular phenotype. Moreover, following Herbertz et al. (2015), we simulate treatment strategies aimed at inhibiting EMT--MET transitions. The results of these simulations will be presented during the presentation. |
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