| Abstract: |
| The interactions between oncolytic viruses (OVs) and innate immunity are crucial for the success of oncolytic therapies. Here we focus on a heterogeneous and plastic population of innate immune cells, the tumour-associated macrophages, that can be involved in the elimination of OVs, as well as in the replication of OVs and their spread across tumour tissue. Computational approaches are used to investigate the importance of different biological mechanisms in the faster spread of OVs, as helped/hindered by different macrophage phenotypes. |
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