| Abstract: |
| In this talk, we show a mathematical model for wound healing caused by exogeneous mechanical stimuli. We here focus on the experimental study which showed exogeneous mechanical forces promote wound healing. In addition, they observed the mechanosensitive ATP release from the leading cells that faced the wound edge and the subsequent intracellular Ca^{2+} ion influx.
We here simulate the experimental study with a mathematical model consisting of the Cellular Pots Model (CPM), which represents the dynamics of cells (collective movement, growth, division, and so on). We assume that the spontaneous cell movement taking into account the cell polarity causes the collective cell movement. We will discuss how the mechanical forces causes the collective cell movement and the consequent promotion of wound healing. And also, we will discuss a force field on the cells calculated by a energy in the CPM. |
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