| Abstract: |
| This paper incorporates the neural photostimulation to model firing activities of the subthalamopallidal network from basal ganglia, and the emphasis is to explore the possible effects of lightgated cation membrane channel on neural system. Motivated by previously proposed computational models of ChR2, we study the firing rhythms of subthalamic nucleus and GPe with different coupling modes, which are closely related with somatic movement. Firstly, the applicability of ChR2 models we employed has been tested and verified through the reaction of single GPe neuron. Then we analyzed the firing patterns of neural population under two prototype network architectures respectively. The sparsely coupled network can produce six general classes of sustained firing patterns with little regularity, while the tightly coupled network can provide five different general waveforms with high correlation, including cluster synchronization of in-phase and anti-phase. Most noteworthy, with the control of ChR2, we found the synchronization of continuous waves can be destroyed and even eliminated under appropriate conditions, which can be an enlightenment for the treatment and regulation of Parkinson`s disease and other motor neural disease related to basal ganglia. |
|