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          | Abstract: |  
          | Dupire recently developed a functional It\^o formula, which has  changed the landscape of the study of stochastic functional equations and encouraged a reconsideration of many problems and applications. Delays are ubiquitous, pervasive, and entrenched in everyday life. Based on the new development, this work examines functional diffusions with two-time scales in which the slow-varying process includes path-dependent functionals and the fast-varying process is a rapidly-changing  diffusion. The gene expression of biochemical reactions occurring in living cells in the introduction of this paper is such a motivating example. This paper establishes mixed functional It\^{o} formulas and the corresponding martingale representation. Then it develops  averaging and weak convergence methods. By treating the fast-varying process as a random ``noise, under appropriate conditions, it is shown that the slow-varying process converges weakly to a stochastic functional differential equation whose coefficients are averages of that of the original slow-varying process with respect to the invariant measure of the fast-varying process. |  |