| Abstract: |
| Radiotherapy is an effective tool in the treatment of cancerous tumors. Dosage strategies currently employed vary form a large single dose or a few large doses (hypofractionation) to many smaller doses (hyperfractionation). These can be derived from a time-dose relationship widely used in radiotherapy, the Linear Quadratic (LQ) model. In this study we determine the optimal radiation dosing strategy, using a novel optimal control technique using mechanistic radiobiological models. |
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